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In addition, there are two alternative pathways involved in nitrogen assimilation in yeast cells (Fig

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Affecting over 25% of American adults and 25%–30% of the global population, this multimorbidity comprises five stages with escalating mortality risk: stages 0–1 (metabolic dysfunction without significant target organ impairment), stages 2–3 (early cardiovascular and kidney injury), and stage 4 (severe cardiovascular events or kidney failure) ( For this review, we searched PubMed, Embase, Web of Science, Cochrane Library, CNKI, and Wanfang Data up from January 2010 to December 2025