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In the anemic baboon model, the level of F-reticulocyte induction by these derivatives was comparable to the level of gamma-globin in baboons previously treated with significantly greater doses of more rapidly metabolized SCFAs, such as butyrate, acetate, propionate, and pentanoic acid (Stamatoyannopoulos et al., 1994)

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ATM-deficient mice, worms, and cell models demonstrated accumulation of cytoplasmic DNA, hyperactivation of PARP1, and low NAD + levels 111,288