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LIST OF ABBREVIATIONS ATP Adenosin-triphosphate Bax/Bcl Pro-apoptotic /anti-apoptotic proteins BBB Blood-brain barrier BDNF Brain-derived neurotrophic factor BPC 157 Stable gastric pentadecapeptide CNS Central nervous system COI Cavities of injury DAMPS Danger associated molecular patterns EGF Epidermal growth factor FGF2 Fibroblast growth factor 2 GLP-1 Glucagon-like peptide-1 GUDCA Glycoursodeoxycholic acid HDACs Inhibitor of histone deacetylases HIF Hypoxia-inducible factor HMGB 1 High mobility group box 1 protein HPA axis Hypothalamus-pituitary-adrenal axis ICU Intensive Care Unit IGF1 Insulin-like growth factor 1 MSC Bone marrow stromal cells NADPH Nicotinamide adenine dinucleotide phosphate NOS Nitric oxide synthase NOX NOXs, NADPH oxidase PGE2 Prostaglandin E2 PRRs Pattern Recognition Receptors ROS Reactive products of oxygen SCFA Short-chain fatty acids SCI Spinal cord injury TBI Trauma brain injury TJs Tight junctions TLR Toll like receptors TMAO Trimethylamine-N-oxide TNFα Tumor necrosis factor Treg Regulatory T cells VEGF Vascular endothelial growth factor CONSENT FOR PUBLICATION Not applicable