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In 2022, BPC-157 was added to the World Anti-Doping Agency (WADA) Prohibited List

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When oxidative stress causes excessive generation of oxygen free radicals, keap1 protein releases Nrf2 through the release of zinc ions, followed by the entrance of Nrf2 into the nucleus to bind to the ARE anti-oxidative stress element sequence, and activates gene transcription downstream of the ARE region, which then initiates the oxidative stress response and reduces the oxidative stress