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Firstly, less adiponectin from adipose tissue reduces the activation of CaMKKβ due to the downregulation of nicotinamide phosphoribosyl transferase (NAMPT), 74,95 leading to a weaker AMPK activity, which can be observed long before the onset of diabetes

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▸ Study 7: REDEFINE 3, cardiovascular outcome trial (ongoing) Citation: NCT05669755, REDEFINE 3 Phase 3 trial