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The effect of citicoline was also evaluated in a multicenter, open-label, controlled trial (IDEALE trial) in Italian elderly adults (ages, 65-94 years) with evidence of vascular lesions on neuroradiology and mild-to-moderate cognitive deficits, as assessed by Mini-Mental State Examination (MMSE

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GHK (in this experiment the peptide alone, not its copper complex, was used) has been proven to quench alpha,beta-4-hydroxy-trans-2-nonenal—a toxic product of fatty acids' lipid peroxidation that play important role in the pathogenesis of several age-related conditions including Alzheimer's disease, neuropathy, and retinopathy [39]