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In addition, mitochondria modulate intracellular calcium homeostasis and immune regulatory pathways (420, 421), which means these pathways may too be compromised in ME/CFS

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In China, for instance, 3 years after the introduction of salt iodisation in 1996, the prevalence of AITD was 0·5 % in an area of mildly deficient iodine intake, 1·7 % in an area of more-than-adequate iodine intake and 2·8 % in an area of excessive iodine intake ( Reference Teng, Shan and Teng 14 )