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It is also not a solubility problem that a better capsule would solve: the compound dissolves readily in both buffer and simulated gastric fluid, and the authors attribute the low bioavailability to poor intestinal absorption plus rapid first-pass metabolism in the liver, where its half-life in hepatocytes was under 7 minutes

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Muscle loss is a significant practical concern, with studies showing that 30-40% of weight lost on GLP-1 agonists can be lean mass if protein intake and resistance training are neglected