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A pilot study examining the efficacy of a vitamin/nutraceutical formulation (NF) (400 µg folic acid, 6 µg vitamin B12, 30 IU vitamin E, 400 mg S-adenosyl methionine, 600 mg N-acetyl cysteine and 500 mg acetyl-L-carnitine) for 12 months in 14 participants with clinically diagnosed early-stage AD reported improved cognitive functions, for example, in the Dementia Rating Scale and clock-drawing tests (Clox 1 and 2) [186]