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In PDQ Cancer information summaries [internet]

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Cellular protection also requires alterations in metabolism and bioenergetics, and although the underlying mechanisms are not well understood, it is becoming increasingly clear that NRF2 activation has a profound effect on mitochondrial function and intermediary metabolism [reviewed in (Dinkova-Kostova and Abramov, 2015, Hayes and Dinkova-Kostova, 2014)]