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observed that the PPARγ and HMGCR protein expression decreased in the liver of HFD rats after atorvastatin intervention (121)

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At the cellular level, B12 acts as a cofactor for two critical enzymatic reactions: Methionine synthase – converts homocysteine to methionine, essential for DNA methylation and synthesis Methylmalonyl-CoA mutase – involved in fatty acid metabolism and myelin production By restoring adequate B12 levels, injections enable normal red blood cell maturation in the bone marrow, correcting the megaloblastic anaemia