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They are vital in maintaining systemic iron equilibrium ( 3+ and transport them to various tissues and organs ( 2+ released from intestinal absorption as well as erythrocyte destruction is oxidized to Fe 3+ by metal oxidases, and the TF-Fe 3+ complex formed by the binding of Fe 3+ to TF, which binds to TFR1 and enters the cells ( 3.1.2 ROS imbalance plays an important role in ferroptosis Lipid peroxidation is the fundamental root cause of ferroptosis, and since lipids make up the majority of cell membranes, they are also the dominating targets of ROS