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To validate the in vivo relevance of our cell culture observations, we subsequently examined the effects of HFD on hepatic protein-SSG adduct formation, IKK-ฮฒ glutathionylation, and NF-ฮบB activation

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3-MA has been shown to inhibit cellular iron uptake and promote iron storage by down-regulating TfR1 levels and increasing ferritin heavy and light chain levels, respectively

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