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More importantly, high concentrations of genistein exhibited stronger antioxidant activity in preventing A β 25–35 -induced neuronal cell death compared to low concentrations of genistein, and at the micromolar level, the neuroprotective effect of genistein is mainly mediated by its antioxidant activity 215 , 216

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Structure-guided optimisation of NMR screen hit The successful soaking of NMR hit analogues 30–32 into TRF1 TRFH crystals validated their site-specific binding and opened up an opportunity to design more analogues in silico