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In these studies, those with electron withdrawing groups in the para position of the phenyl fraction were highlighted as having the greatest activity, in particular compound 69 , containing bromine in this position, showed the best inhibitory activity against XO (IC 50 = 1.79 µM), almost 10 times more effective than allopurinol (IC 50 = 10.73 µM) (Figure 21)

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