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The FDA notes the most severe adverse events include melanoma, posterior reversible encephalopathy syndrome, sympathomimetic toxidrome, and prolonged and painful boners

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A recent study found that the ferroptosis inducer erastin can induce cellular autophagy, and autophagy can trigger ferroptosis by degrading ferritin and transferrin receptor 1 (TfR1), resulting in the accumulation of intracellular iron