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Nowadays, a nonavalent vaccine is on the market (Gardasil ® 9), targeting the HPV types 6, 11, 16, 18, 31, 33, 45, 52 and 58, respectively ( While mucosal HPVs are sexually transmitted and infection is age-dependent, cutaneous HPVs are part of the commensal skin microbiome that is passively acquired early after birth ( Organ transplant recipients have an increased risk of developing NMSC ( In the HPV16 RG1-VLP vaccine, the HPV16 RG1 epitope is genetically inserted into the immunogenic DE-surface loop of HPV16 L1 and displayed on the surface of assembled VLPs in a repetitive, closely spaced and highly immunogenic fashion ( in vivo cross-protection against all clinically relevant high-risk mucosal HPV types responsible for up to ~96% of all cervical cancers and several low-risk types
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