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81 In stimulated chondrocytes, however, NAC does not appear to significantly affect the synthesis of the aforementioned inflammatory mediators, indicating that this supplement might display a more symptomatic effect on the synovium instead of a structural effect on cartilage

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Similarly, the active form of Folic Acid is called 5-Methyltetrahydrofolate (or 5-MTHF) and it too has a methyl group attached and ready to donate