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In GCF concentrations of glutathione (range 0.5-2.5 mM) were reported to be 1000 times greater than that normally detected within extracellular tissue compartments (0.5-5 μM in human plasma).[29] The high levels of glutathione within GCF may be the result of increased synthesis by cells of the periodontal tissues, or of active release mechanisms or passive release secondary to protease activity on gingival epithelial cells.[4] Neutrophils and/or junctional/crevicular epithelium (JE) are significant contributors for the high concentrations of glutathione in GCF

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