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HO-1 is the major and rate-limiting enzyme of heme metabolism, which catalyzes the catabolism of heme to biliverdin, free iron, and carbon monoxide, and HO-1 deficiency exacerbates ROS accumulation, lipid peroxidation, and iron overload in hepatocytes [146]

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They may also interact with certain foods, including dairy products, soy products, and certain fruits and vegetables