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Nicotinamide N-methyltransferase (NNMT), an enzyme associated with fat storage and reduced energy expenditure, is inhibited by this small molecule

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Common hormonal drivers of brain fog: Estrogen fluctuations (perimenopause, menopause) Progesterone deficiency Testosterone imbalance (in both women and men) Thyroid dysfunction Cortisol dysregulation (burnout) This is why brain fog is so common in: Perimenopause and menopause Postpartum periods High-stress professionals Individuals with disrupted sleep or circadian rhythms Hormonal brain fog is often misdiagnosed as anxiety, depression, or ADHD