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The secoiridoid prevented LPS/IFN-γ-induced inflammatory cytokine production by macrophages through the NF-κB (nuclear factor kappa) signaling pathway in vitro , and might exert a protective role by suppressing pro-inflammatory cytokine production by macrophages

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Stacking this with metformin or SGLT2 inhibitors requires extreme caution to avoid severe metabolic dampening or clinical frailty