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GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses

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However, no difference between ME/CFS patients and controls was found with respect to autoantibodies against serotonin, angiotensin, endothelin, mu-opioid, and dopamine (503, 504)