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Introduction Several independent studies have now established a significant association between the outcome of COVID-19 and previously documented regional selenium (Se) status in Chinese cities ( Most (but not all) of the biological roles of Se, both as selenocysteine in selenoproteins, and as redox-active Se-containing metabolites, involve interactions with cysteine thiols and disulfides in proteins and peptides, and their various oxidized forms

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Two examples of bioactivation of endogenous compounds will be discussed here, namely, catecholamines and estrogens