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Biohacking culture People want to optimize performance and longevity Social media influence Peptides are widely promoted as recovery “shortcuts” Frustration with slow healing = lack of education by providers on how long tendon/ligament injuries can take to “repair” Athletes often seek ways to speed recovery beyond natural timelines A Major Concern: Unregulated Products Currently: most peptides are not approved by Health Canada or the FDA manufacturing is largely unregulated quality control is inconsistent This makes it difficult to verify: product purity dosing accuracy contamination risk Current Medical Consensus “Peptides show biological promise in preclinical research but lack sufficient human evidence for routine clinical use” Important unknowns include: dosing frequency duration long-term safety How Group23 Approaches Regenerative Medicine At Group23 Sports Medicine, we focus on treatments supported by the strongest evidence: structured rehabilitation programs under physiotherapy supervision load management and strength training – ideally with strength and conditioning coach platelet-rich plasma (PRP) soft tissue adapted biocompatible hyaluronic acid injections → SportVis – see www.sportvis.ca high molecular weight cross linked hyaluronic acid injections → Monovisc (see www.monovisc.ca), Synolis VA (see www.synolis.com) and Durolane (www.durolane.ca/en/) Blood Flow Restriction (BFR) therapy (see off the shelf and custom bracing strategies These treatments currently have far stronger clinical evidence than experimental peptide therapies

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10.1515/9783110527872-009 27 CuiY.ZhangY.ZhaoX.ShaoL.LiuG.SunC.et al (2021)