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24 24 24 The exact mechanism by which chromium influences CRP levels is not precisely known, but it is suggested that its inhibitory effect on pro-inflammatory cytokines is related to the reduction of oxidative stress, which decreases CRP 24 24 25 SELENIUM It is an essential trace element with antioxidant properties, fundamental for selenoproteins that regulate the function of endothelial cells and protect against oxidative damage

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110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that β-elemene is a novel inducer of ferroptosis