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Between one and three months of regular application, most users begin to observe noticeable fading of hyperpigmented areas, with dark spots becoming lighter and more diffuse as melanin-laden cells are gradually replaced with evenly pigmented ones

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IGF-1 LR3 binds the alpha subunit of the IGF-1 receptor tyrosine kinase, inducing autophosphorylation of the beta subunit on specific tyrosine residues (Y1131, Y1135, Y1136) that create docking sites for insulin receptor substrate (IRS) proteins and Shc adaptor proteins