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A small percentage of mice with only one copy of the GPx-1 allele and complete deficiency of GPx-2 develop mild ileocolitis (GPx-1 +/− GPx-2 −/− ), whereas a single copy of the GPx-2 gene (GPx-1 −/− GPx-2 +/− ) protects against inflammation, leading to the suggestion that GPx-2 has a greater protective effect in the intestine than GPx-1 (114), although an earlier study reported that one copy of either of these GPx genes was sufficient to prevent the development of intestinal cancer (72)