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Because TB-500 reaches all tissues rather than concentrating at one site, the dosing strategy focuses on sustaining a systemic therapeutic level across the cycle rather than targeting a precise anatomical location

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A Cu(II) complex with the Dp44 mT ligand, which is presently in clinical trials (NCT02688101), exhibited the highest anticancer competency compared to the Cu(II) complex with 3AP through balancing between moderate depletion of GSH level and ROS generation