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Obesity Treatment is Being Explored Through the Development of Oral Medications that Function as GLP- 1 Receptor Agonists Semaglutide A randomized, double-blind, phase III study found that giving adults overweight or obese (without T2DM) 50 mg of oral semaglutide once daily for 68 weeks, in addition to diet and exercise, significantly reduced their body weight in comparison with a placebo (15% vs