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Crosstalk between oxidative stress and inflammatory nodes is central to this network: PI3K/AKT can promote Nrf2 activation and antioxidant gene expression, while activated Nrf2 dampens NF-κB–driven transcription and limits ROS-mediated injury (Gao et al., 2022

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If you're transitioning off a hormonal medication like spironolactone, your skin is already in flux