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Components of the ER-associated degradation (ERAD) pathway—including Syvn1, Sel1l, Derl3, Amfr, and Ubxn4—were also reduced, along with genes involved in vesicular trafficking (Sec24a, Sec24c, Sec24d, Sec23b, Sec31a, Sar1a, Sec61a1, Ssr3), suggesting a global decline in secretory activity

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Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): involvement of hypoxia-inducible factor 1α (Hif-1α) and heme oxygenase (HO-1)