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GSH improves the health and quality of mitochondria as it directly provides free glutathione which can assist cellular metabolism through the prevention of anomalies and dysfunction of mitochondria, the organelle responsible for cellular energy production

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Moreover, IL-6 modulates claudin-2 protein expression through IL-6Rα-associated signaling transducers and gp130 signaling pathway, consequently enhancing TJ permeability in intestinal epithelium (129)