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In ALS patients plasma IGF-1 levels were reduced, suggesting that the Growth hormone (GH)/IGF-1 axis could be a serological marker of some specific neuronal degeneration 8

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A subgroup analysis from the meta-analysis, however, found that the Leu allele was significantly associated with risk in African Americans, using either an additive (odds ratio = 1.91, 95% confidence interval [CI]: 1.02–3.58) or recessive (odds ratio = 2.09, 95% CI: 1.16–3.76) model, suggesting the need for additional studies, as the numbers of cases in this subgroup were small (173)