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Compound extraction from tissue and plasma For Th-2-31, extraction from plasma was performed by adding 900 μL acetonitrile to 100 μL plasma, sonicating to mix, and incubating on ice for 2 h for optimal extraction

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On the contrary, the Enos isoform, which is localized to the microvasculature at the submucosa–mucosa interface, catalyzes the capillary recruitment of absorptive hyperemia