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1 Why NAD+ and Mitochondrial Function Matter Maintaining enough NAD+ is crucial because it activates several important processes, including: 7 Cellular signaling and metabolic regulation Cellular energy production and oxidative metabolism DNA repair enzymes and sirtuin (proteins that protect and repair) activity Mitochondria need a constant supply of NAD+ to make ATP

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[DOI] [PubMed] [Google Scholar] 124.Drucker DJ, Buse JB, Taylor K, et al