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Cagrilintide and semaglutide work through different mechanisms and have different dosing schedules: Cagrilintide: Amylin receptor agonist Escalation: 0.6 mg → 1.2 mg → 2.4 mg weekly Three-step titration over 8 weeks Semaglutide: GLP-1 receptor agonist Escalation: 0.25 mg → 0.5 mg → 1.0 mg → 1.7 mg → 2.4 mg weekly Five-step titration over 16-20 weeks When combined in CagriSema, both peptides are dosed at 2.4 mg weekly, representing the maximum studied dose for each component

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[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Steven S., Frenis K., Oelze M., Kalinovic S., Kuntic M., Jimenez M.T.B., Vujacic-Mirski K., Helmstädter J., Kröller-Schön S., Münzel T., et al