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38,39 Glutamine traverses the plasma membrane via amino acid transporter type 2 (ASCT2) and sodium-coupled neutral amino acid transporter 5 (SN2), where cytosolic glutaminase converts it to glutamate and then to α-ketoglutarate (α-KG), which enters the TCA cycle

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Lyophilized (unreconstituted) tirzepatide should be stored at controlled room temperature or refrigerated, depending on the manufacturer instructions