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Structuur-activiteitsonderzoek waarbij het motief Gly-His-Lys systematisch wordt gevarieerd of verlengd

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At the central level, excessive prolactin inhibits the synthesis and pulsatile secretion of hypothalamic gonadotropin-releasing hormone (GnRH), thereby reducing the release of pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone, ultimately leading to hypogonadism (57)