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SIRT6 directly interacts with and deacetylates STAT5, inhibiting IL-15/JAK3-induced translocation of STAT5 from the cytoplasm to the nucleus and inactivating IL-15/JAK3/STAT5 signalling, which depresses chondrocyte senescence (169)

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This cataploretic step promotes acetyl-CoA accumulation in the cytoplasm and favors acetylation of cytoplasmic proteins