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2015;81(2):E61–3

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LDs are not merely depots of neutral lipids (triacylglycerols and cholesteryl esters), but active participants in lipogenesis, lipolysis, and detoxification of lipid excess ( Mitochondria adjacent to LDs, so-called peridroplet mitochondria (PDMs), display distinct functional properties, including increased ATP synthesis and a specific proteome that favors the energy-efficient formation of new LDs and protects the cell from lipotoxicity ( 2+ dysregulation, oxidative stress, and necrotic cell death ( In AP, LD–mitochondria interactions undergo profound alterations as part of the pathogenic mechanism of PAC injury